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On Linux, it seems to be a convention that programs using a serial port should lock the port for exclusive access using flock(fd, LOCK_EX | LOCK_NB), or else fail with an error to indicate the serial port is already in-use.
It would be good if System.IO.Ports SerialPort would implement this locking on Linux.
https://stackoverflow.com/q/29482327/60075 "Locking a Linux serial port or other device in Mono"
https://stackoverflow.com/q/30316722/60075 "What is the best practice for locking serial ports and other devices in Linux?"